Page 3 of 7 msds t acetonitrile flames and sparks, of heat, of oxidizing materials. Accidental release measures contain spill and collect, as appropriate. Burning sodium perchlorate may produce chlorine, chlorine dioxide, hydrogen chloride, and oxides of nitrogen as well as mixtures with any other compounds involved in the combustion. Cas registry number chemical abstracts service 0000322350. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The invention provides a onestep method for quickly preparing benserazide hydrochloride.
Buy benserazide hydrochloride online at lgc standards. Hydrogen chloride gas forms at temperatures above 2732f. A list of us medications equivalent to benserazide hydrochloride is available on the website. Benserazide is a carbohydrazide that results from the formal condensation of the carboxy group of dlserine with the primary amino group of 4hydrazinylmethylbenzene1,2,3triol. Identification product name pyridoxine hydrochloride cat no. Levodopa is a prodrug of dopamine that is administered to patients with parkinsons due to its ability to cross the bloodbrain barrier. Benserazide hydrochloride safety data sheet section 2. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves. When heated to decomposition, emits toxic hydrogen chloride fumes and will react with water or steam to produce heat and toxic and corrosive fumes. When given with levodopa, benserazide produces higher brain concentrations of dopamine with lower doses of levodopa, thus lessening the side effects seen with higher doses. Singledose study of slow release preparation of levodopa and benserazide madopar hbs. Benserazide hydrochloride can be analyzed by this reverse phase rp hplc method with simple conditions. Sigmaaldrich offers a number of benserazide hydrochloride products.
If you accept without changing your settings, we assume that you are happy to receive all cookies on the lgc website. The specifications for content of specific degradation products of benserazide hydrochloride are limited to 3. Chemical product and company identification product name. An aromaticlaminoacid decarboxylase inhibitor dopa decarboxylase inhibitor that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of. Oel fastrac is a convenient and affordable way for pharmaceutical, biotechnology, medical device and other life science companies. Transfer to a chemical waste container for disposal in accordance with local regulations. Copying of any msds displayed is permitted for personal use only and otherwise is not permitted. In a reaction solvent selected from water, ethanol, isopropanol, and glycol dimethyl ether, in the presence of hydrogen and a catalyst, serine hydrazide hydrochloride and 2,3,4trihydroxybenzaldehyde are subjected to a reaction to obtain benserazide hydrochloride. Global benserazide hydrochloride cas 14919778 manufacturing, technology, market landscape and distribution policy report 2016 research and markets november 30, 2016 02. Gain reliable data with our benserazide hydrochloride reference standards. Benserazide hydrochloride european pharmacopoeia ep reference standard synonym.
Risks of explosion of the product in presence of mechanical impact. Benserazide also called serazide or ro 44602 is a peripherally acting aromatic lamino acid decarboxylase or dopa decarboxylase inhibitor, which is unable to cross the bloodbrain barrier indications. This protein is responsible for decarboxylating ldopa to dopamine, 5hydroxytryptophan to serotonin, and tryptophan to tryptamine. The company operates in more than 30 countries and delivers an extensive portfolio of products and services. Apr 23, 20 benserazide is degradated by hydrolysis to ro 041419, which can bind one molecule of benserazide to the dimer ro 081580.
Before using benserazide hydrochloride, inform your doctor about your current list of medications, over the counter products e. Levodopanormal motor function depends on the synthesis and release of dopamine by neurons projecting from substantia nigra to corpus striatum. In particular the msds s displayed cannot be copied for the purpose of sale or licence or for inclusion as part of a collection of msds without the express written consent of acohs pty ltd. For research use only, not for human or veterinary use. A provided synthetic method for an intermediate of benserazide hydrochloride comprises the following steps. China benserazide hydrochloride, benserazide hydrochloride.
Benserazide definition of benserazide by medical dictionary. Neonatal dosage 3kg not recommended in his age group. The chromatographic procedure may be carried out using. The ideal choice for forensic and toxicology testing. Airgas usa, llc and its affiliates 259 north radnorchester road suite 100 radnor, pa. The mobile phase contains an acetonitrile mecn, water, and phosphoric acid. High quality cas 14919778 benserazide hydrochloride. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020, wolters kluwer updated. An aromaticlaminoacid decarboxylase inhibitor dopa decarboxylase inhibitor that does not enter the central nervous system, it is used as its hydrochloride. Benserazide hcl, 14919778, benzerazide hydrochloride, dlserine 2, ccris 5092, ro 44602001. Dl serine 2 2,3,4trihydroxybenzylhydrazide hydrochloride. Benserazide hydrochloride is a medicine available in a number of countries worldwide. Hydrogen chloride hcl hazardous decomposition products section 10. Intermediates of benserazide hydrochloride, manufacturer.
Benserazide hydrochloride 14919778 tokyo chemical industry co. Safety data sheet creation date 15dec2011 revision date 04mar2019 revision number 5 1. Toxicological information eye irritation hazardous in case of eye contact irritant. For massspec ms compatible applications the phosphoric acid needs to be replaced with formic acid. Msdssds database search a safety data sheet sds,material safety data sheet msds, or product safety data sheet psds is a document that lists information relating to occupational safety and health for the use of various substances and products. Technical details about benserazide hydrochloride, learn more about the structure, uses, toxicity, action, side effects and more benserazide hydrochloride also known as. Affygility solutions ehs compliance management software. Thermal oxidative decomposition produces toxic chlorine fumes and explosive hydrogen gas. Costentin, in presynaptic receptors and neuronal transporters, 1991. Benserazide hydrochloride european pharmacopoeia 6. Benserazidehcl ro 44602 is a small molecule inhibitor of extracerebral ddc aromatic laminoacid decarboxylase, also known as dopa decarboxylase.
Material safety data sheet inhibited hydrochloric acid 15%. Benserazide hydrochloride einecs no 14919778 place of origin. Vitamin b6 hydrochloride recommended use laboratory chemicals. Type the keywords youre interested in such as benserazide hydrochloride and make direct contact with any desirable suppliers manufacturers wholesalers for more important details or find similar choices that are 14919778, cheap benserazide hcl, discount pharmaceutical chemicals. China benserazide hydrochloride manufacturers, suppliers. Risks of explosion of the product in presence of static discharge. Toxic by inhalation, in contact w ith skin and if swallowed.
Benserazide hydrochloride 14919778 buy and find out price and availability, msds, properties of tcis high quality specialty chemicals. Aldrich w292907 page 1 of 8 sigmaaldrich material safety data sheet version 5. The progressive degeneration of these neurons that occurs in parkinsons. Section 16 additional information msds creation date. Extreme high moderate low section 1 chemical product and company identification product name benserazide. Explosion hazards in presence of various substances. High quality reference standards for the most reliable pharmaceutical testing. High quality cas 14919778 benserazide hydrochloride benserazide hcl quick details cas no 14919778 other names. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Fluka 12070 page 1 of 6 sigmaaldrich material safety data sheet version 3. Airgas usa, llc and its affiliates 259 north radnorchester road suite 100 radnor, pa 190875283. Methods and material for containment and cleaning up. Hcl ro 44602 statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Msdssds database search safety data sheets library chemsrc.
Some health conditions may make you more susceptible to the sideeffects of the drug. If you can not locate your required intermediate for benserazide hydrochloride on this page, you may send us a sourcing request for the specific benserazide hydrochloride intermediate you are looking for along with its cas no, and the intermediate name and we shall come back to you promptly with more. As our channel brand, vwr offers an integrated, seamless purchasing experience that is optimized for the way our. Every single member from our large efficiency revenue team values customers wants and company communication for benserazide hydrochloride, 4hydroxy3methoxybenzylamine hydrochloride, 3hydroxybutyric acid sodium, 62765, sincerely hope we are growing up together with our customers all over the world. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. It is used in the management of parkinsons disease in combination with ldopa as cobeneldopa, under the brand names madopar in the uk and prolopa in canada, both made by roche. Benserazide hydrochloride drug information, uses, side. Hydrochloric acid, 37% ww 7647010 ld50 oral rat 700 mgkg. However, we make no warranty of merchantability or any other warranty, express or implied, w ith respect to such information, and we assume no liability resulting from its use.
Empirical formula hill notation c 10 h 15 n 3 o 5 hcl. Dose single dose frequency route instructions adult dosage. Benserazide hydrochloride european pharmacopoeia ep. Benserazide hydrochloride china ningbo nfc chemical. Each madopar hbs 125 capsule 100 mg levodopa and 28. Benserazide is a carbohydrazide that results from the formal condensation of the carboxy group of dlserine with the primary amino group of 4 hydrazinylmethylbenzene1,2,3triol. We use cookies to ensure that we give you the best experience of our website. The solubility of benserazide hydrochloride in these solvents is approximately 16 and 20 mgml, respectively. Benserazide hydrochloride is a peripherallyacting aromatic lamino acid decarboxylase aaad or dopa decarboxylase inhibitortarget. Msds contains all of the information required by those regulations. Stability and reactivity low order of acute toxicity. It is our responsibility to meet your needs and efficiently serve you. Since 2002, affygility solutions has been providing potent compound safety, occupational toxicology and industrial hygiene services to biotechnology, pharmaceutical and medical device companies throughout the world.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Identification of the substancemixture and of the companyundertaking product name. Dopa decarboxylasebenserazide is commonly used for parkinsons disease in combination with ldopa as a peripheral aromatic lamino acid decarboxylase aadc inhibitor. Suppliers list, emailrfq form, molecular structure, weight, formula, iupac, synonyms for benserazide hydrochloride cas no. Benserazide hydrochloride c10h16cln3o5 cid 26964 structure, chemical names, physical and chemical properties, classification, patents, literature. Potential health effects do not induce vomiting because of danger of aspirating liquid into lungs. Bp2677100 casno 58560 synonyms 3hydroxy4,5dimethylolalphapic. Material safety data sheet of benserazide hydrochloride. Material safety data sheet perchloric acid, 70% msds section 1. Eye contact skin contact inhalation ingestion immediately flush eyes with running water for at least 15 minutes, keeping eyelids open.
Levodopa can be metabolised to dopamine on either side of the bloodbrain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the bloodbrain barrier. Levodopa and benserazide drug information, professional. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. These combinations are also used for the treatment of restless legs syndrome. Dlserine 22,3,4trihydroxybenzyl hydrazide hydrochloride cas number 14919778. Popaedriatic dosage 20kg not recommended in this age group. Safety data sheet northwest missouri state university. Safety data sheet ghs product identifier other means of identification emergency telephone number with hours of operation section 1. Benserazide hcl is a peripherallyacting aromatic lamino acid decarboxylase aaad or dopa decarboxylase inhibitor. These are common byproducts of combustion and are likely to be serious health concern. Pharmaceutical quality of seven generic levodopabenserazide. It is used in the management of parkinsons disease in combination with ldopa levodopa as cobeneldopa ban, under the brand names prolopa in canada and madopar in the uk, both made by roche. Animal pharmaceuticals, pharmaceutical raw materials.
118 460 1414 1338 478 616 560 580 140 1124 1090 221 55 1010 33 364 1150 809 59 748 399 830 1388 969 1544 1538 953 764 414 1456 1001 87 237 133 412 1431 225 900 158 1130 376 998